@article {Xu2014a, title = {Accuracy analysis in MRI-guided robotic prostate biopsy}, year = {2014}, month = {03/2014}, pages = {43}, url = {http://www.imno.ca/sites/default/files/2014Proceedings.pdf}, author = {Xu, Helen and Andras Lasso and Peter Guion and Axel Krieger and Aradhana Kaushal and A.K. Singh and P.A. Pinto and Jonathan Coleman and R.L. Grubb III and Jean-Baptiste Lattouf and Cynthia Menard and L.L. Whitcomb and Gabor Fichtinger} } @article {Xu2013b, title = {Accuracy analysis in MRI-guided robotic prostate biopsy}, journal = {International Journal of Computer Assisted Radiology and Surgery}, volume = {8}, number = {6}, year = {2013}, month = {03/2013}, pages = {937-944}, doi = {10.1007/s11548-013-0831-9}, author = {Xu, Helen and Andras Lasso and Peter Guion and Axel Krieger and Aradhana Kaushal and Anurag K. Singh and P.A. Pinto and Jonathan Coleman and R.L. Grubb III and Jean-Baptiste Lattouf and Cynthia Menard and Whitcomb, Louis L. and Gabor Fichtinger} } @article {Xu2013, title = {Accuracy analysis in MRI-guided robotic prostate biopsy}, volume = {8}, number = {1}, year = {2013}, pages = {211}, publisher = {Springer}, address = {Heidelberg, Germany, June 26-29}, author = {Xu, Helen and Andras Lasso and Peter Guion and Axel Krieger and Aradhana Kaushal and Anurag K. Singh and P.A. Pinto and Jonathan Coleman and R.L. Grubb III and Jean-Baptiste Lattouf and Cynthia Menard and Whitcomb, Louis L. and Gabor Fichtinger} } @article {Singh2007a, title = {Patient selection determines the prostate cancer yield of dynamic contrast-enhanced magnetic resonance imaging-guided transrectal biopsies in a closed 3-Tesla scanner}, journal = {British Journal of Urology international}, volume = {101}, number = {2}, year = {2007}, month = {Jan}, pages = {181{\textendash}185}, publisher = {Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1642, USA Anurag Singh@RoswellPark org}, abstract = {

OBJECTIVE: To evaluate the cancer yield of transrectal prostate biopsies in a 3-T magnetic resonance imaging (MRI) scanner in patients with elevated prostate specific antigen (PSA) levels, recent negative transrectal ultrasonography (TRUS)-guided prostate biopsies PATIENTS AND METHODS: Between July 2004, November 2005, patients with at least one previous negative prostate biopsy within the previous 12 months had MRI-guided biopsy of the prostate in a 3-T MRI scanner Patients with previous positive biopsies for cancer were excluded Target selection was based on T2-weighted imaging, dynamic contrast-enhanced (DCE) imaging studies RESULTS: Thirteen patients were eligible; their median (range) age was 61 (47-74) years, PSA value 4 90 (1 3-12 3) ng/mL Most patients had one previous negative biopsy (range 1-4) Four patients had a family history of prostate cancer There were 37 distinct targets based on T2-weighted imaging Fifteen of 16 distinct DCE abnormalities were co-localized with a target based on T2-weighted imaging Despite this correlation, only one of 13 patients had a directed biopsy positive for cancer Including systematic biopsies, two of 13 patients had a biopsy positive for prostate cancer One patient had prostate intraepithelial neoplasia, one had atypical glands in the specimen CONCLUSION: The prostate-cancer yield of transrectal biopsies in a 3-T MRI scanner, among patients with recent negative TRUS-guided prostate biopsies, is similar to repeat systematic TRUS-guided biopsy DCE correlates with T2-imaging but does not appear to improve prostate cancer yield in this population

}, keywords = {Aged, Biopsy, blood, Cohort Studies, Contrast Media, diagnosis, Digital Rectal Examination, Humans, Interventional, Magnetic Resonance Imaging, Male, methods, Middle Aged, Needle, pathology, Patient Selection, Predictive Value of Tests, Prostate, Prostate-Specific Antigen, Prostatic Neoplasms, Sensitivity, Specificity, standards, Ultrasonography}, doi = {10 1111/j 1464-410X 2007 07219 x}, url = {http://dx doi org/10 1111/j 1464-410X 2007 07219 x}, author = {Anurag K. Singh and Axel Krieger and Jean-Baptiste Lattouf and Peter Guion and R.L. Grubb III and Paul Albert and Greg Metzger and Karen Ullman and Sharon Smith and Gabor Fichtinger and Iclal Ocak and Peter Choyke and Cynthia Menard and Jonathan Coleman} } @article {Susil2006, title = {Transrectal prostate biopsy and fiducial marker placement in a standard 1 5T magnetic resonance imaging scanner}, journal = {The Journal of Urology}, volume = {175}, number = {1}, year = {2006}, month = {Jan}, pages = {113{\textendash}120}, publisher = {Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA}, abstract = {

PURPOSE: We investigated the accuracy, feasibility of a system that provides transrectal needle access to the prostate concurrent with 1 5 Tesla MRI which previously has not been possible MATERIALS AND METHODS: In 5 patients with previously diagnosed prostate cancer, MRI guided intraprostatic placement of gold fiducial markers (4 procedures),/or prostate biopsy (3 procedures) was performed using local anesthesia RESULTS: Mean procedure duration was 76 minutes, all patients tolerated the intervention well Procedure related adverse events included self-limited hematuria, hematochezia following 3 of 8 procedures (all resolved in less than 1 week) Mean needle placement accuracy was 1 9 mm for the fiducial marker placement studies, 1 8 mm for the biopsy procedures Mean fiducial marker placement accuracy was 4 8 mm, the mean fiducial marker placement accuracy transverse to the needle direction was 2 6 mm All patients who underwent the procedure were able to complete their course of radiotherapy without delay or complication CONCLUSIONS: While studies of clinical usefulness are warranted, transrectal 1 5 T MRI guided prostate biopsy, fiducial marker placement is feasible using this system, providing new opportunities for image guided diagnostic, therapeutic prostate interventions

}, keywords = {Biopsy, Equipment Design, Feasibility Studies, Humans, instrumentation, instrumentation/methods, Magnetic Resonance Imaging, Male, Needle, pathology, Prostate, Prostatic Neoplasms}, doi = {10 1016/S0022-5347(05)00065-0}, url = {http://dx doi org/10 1016/S0022-5347(05)00065-0}, author = {Robert Susil and Cynthia Menard and Axel Krieger and Jonathan Coleman and Kevin Camphausen and Peter Choyke and Gabor Fichtinger and Whitcomb, Louis L. and Norman Coleman and Ergin Atalar} } @article {Krieger2005a, title = {Design of a novel MRI compatible manipulator for image guided prostate interventions}, journal = {IEEE Transactions on Biomedical Engineering}, volume = {52}, number = {2}, year = {2005}, month = {Feb}, pages = {306{\textendash}313}, abstract = {

This paper reports a novel remotely actuated manipulator for access to prostate tissue under magnetic resonance imaging guidance (APT-MRI) device, designed for use in a standard high-field MRI scanner The device provides three-dimensional MRI guided needle placement with millimeter accuracy under physician control Procedures enabled by this device include MRI guided needle biopsy, fiducial marker placements, and therapy delivery Its compact size allows for use in both standard cylindrical, open configuration MRI scanners Preliminary in vivo canine experiments, first clinical trials are reported

}, keywords = {Animals, Biopsy, Computer-Assisted, Dogs, Equipment Design, Equipment Failure Analysis, Feasibility Studies, Imaging, instrumentation/methods, Magnetic Resonance Imaging, Male, Micromanipulation, Needle, pathology/surgery, Prostate, Reproducibility of Results, Robotics, Sensitivity, Specificity, Surgery, Three-Dimensional}, doi = {10 1109/TBME 2004 840497}, url = {http://dx doi org/10 1109/TBME 2004 840497}, author = {Axel Krieger and Robert Susil and Cynthia Menard and Jonathan Coleman and Gabor Fichtinger and Ergin Atalar and Whitcomb, Louis L.} } @article {Menard2005, title = {An Interventional MRI Technique for the Molecular Characterization of Intra-Prostatic Dynamic Contrast Enhancement}, journal = {Molecular Imaging}, volume = {4 No 1}, year = {2005}, pages = {63-66}, author = {Cynthia Menard and Robert Susil and Peter Choyke and Jonathan Coleman and R.L. Grubb III and Ahmed Gharib and Axel Krieger and Peter Guion and David Thomasson and Karen Ullman and Sandeep Gupta and Virginia Espina and Lance Liotta and Emanuel Petricoin and Gabor Fichtinger and Whitcomb, Louis L. and Ergin Atalar and Norman Coleman and Kevin Camphausen} } @conference {Krieger2005, title = {MRI Guided Prostate Interventions in 3T}, booktitle = {International Society of Magnetic Resonance in Medicine (ISMRM)}, year = {2005}, author = {Axel Krieger and Peter Guion and Abdel-Monem El-Sharkawy and Greg Metzger and Jonathan Coleman and R.L. Grubb III and Di Qian and Ahmed Gharib and David Thomasson and Anurag K. Singh and Gabor Fichtinger and Whitcomb, Louis L. and Cynthia Menard and Ergin Atalar} } @conference {Menard2004, title = {Integrating Diagnostic and Interventional MRI for the Molecular Characterization of Prostate Cancer}, booktitle = {5th Interventional MRI Symposium}, year = {2004}, author = {Cynthia Menard and Robert Susil and Peter Choyke and Jonathan Coleman and R.L. Grubb III and Axel Krieger and Ahmed Gharib and Peter Guion and David Thomasson and Jacek Capala and Sandeep Gupta and Gabor Fichtinger and Whitcomb, Louis L. and Norman Coleman and Kevin Camphausen and Ergin Atalar} } @conference {Menard2004a, title = {MRI For The Molecular Characterization Of Prostate Cancer Integrating Diagnostic And Interventional MRI For The Molecular Characterization Of Prostate Cancer}, booktitle = {5th Interventional MRI Symposium}, year = {2004}, pages = {26}, author = {Cynthia Menard and Robert Susil and Peter Choyke and Jonathan Coleman and R.L. Grubb III and Axel Krieger and Ahmed Gharib and Peter Guion and David Thomasson and Jacek Capala and Sandeep Gupta and Gabor Fichtinger and Whitcomb, Louis L. and Norman Coleman and Kevin Camphausen and Ergin Atalar} } @conference {Krieger2004a, title = {A Novel MRI Compatible Manipulator for Prostate Interventions}, booktitle = {Annual Meeting of International Society of Magnetic Resonance in Medicine (ISMRM)}, year = {2004}, author = {Axel Krieger and Robert Susil and Cynthia Menard and Jonathan Coleman and Gabor Fichtinger and Whitcomb, Louis L. and Ergin Atalar} } @conference {Coleman2004, title = {Technique and Accuracy of a Clinical System for Transrectal Intraprostatic Needle Placement in a Standard 1 5T MRI Scanner}, booktitle = {American Urological Association}, year = {2004}, author = {Jonathan Coleman and Robert Susil and Axel Krieger and Peter Choyke and Betty Wise and David Thomasson and Ahmed Gharib and Whitcomb, Louis L. and Gabor Fichtinger and Marston Linehan and Norman Coleman and Kevin Camphausen and Ergin Atalar and Cynthia Menard} } @conference {Susil2004a, title = {Transrectal Prostate Biopsy and Fiducial Marker Placement in a Standard 1 5T MRI Scanner}, booktitle = {Annual Meeting of International Society of Magnetic Resonance in Medicine (ISMRM)}, year = {2004}, author = {Robert Susil and Cynthia Menard and Axel Krieger and Jonathan Coleman and Kevin Camphausen and Peter Choyke and Karen Ullman and Sharon Smith and Gabor Fichtinger and Whitcomb, Louis L. and Norman Coleman and Ergin Atalar} } @article {Balogh2004, title = {Visualization, Planning, and Monitoring Software for MRI-Guided Prostate Intervention Robot}, journal = {Proceedings Lecture Notes in Computer Science Medical Image Computing and Computer-Assisted Intervention (MICCAI)}, volume = {3217}, year = {2004}, pages = {73-80}, author = {Emese Balogh and Anton Degeut and Robert Susil and Axel Krieger and Anand Viswanathan and Cynthia Menard and Jonathan Coleman and Gabor Fichtinger} } @conference {Susil2003a, title = {An MRI System for Guidance and Monitoring of Transrectal Prostate Interventions in a 1 5T Scanner}, booktitle = {Radiological Society of North America, 89th Scientific Assembly}, year = {2003}, author = {Robert Susil and Axel Krieger and Cynthia Menard and Jonathan Coleman and Kevin Camphausen and Peter Choyke and Norman Coleman and Whitcomb, Louis L. and Gabor Fichtinger and Ergin Atalar} }