@article {Xu2014a, title = {Accuracy analysis in MRI-guided robotic prostate biopsy}, year = {2014}, month = {03/2014}, pages = {43}, url = {http://www.imno.ca/sites/default/files/2014Proceedings.pdf}, author = {Xu, Helen and Andras Lasso and Peter Guion and Axel Krieger and Aradhana Kaushal and A.K. Singh and P.A. Pinto and Jonathan Coleman and R.L. Grubb III and Jean-Baptiste Lattouf and Cynthia Menard and L.L. Whitcomb and Gabor Fichtinger} } @article {Xu2013b, title = {Accuracy analysis in MRI-guided robotic prostate biopsy}, journal = {International Journal of Computer Assisted Radiology and Surgery}, volume = {8}, number = {6}, year = {2013}, month = {03/2013}, pages = {937-944}, doi = {10.1007/s11548-013-0831-9}, author = {Xu, Helen and Andras Lasso and Peter Guion and Axel Krieger and Aradhana Kaushal and Anurag K. Singh and P.A. Pinto and Jonathan Coleman and R.L. Grubb III and Jean-Baptiste Lattouf and Cynthia Menard and Whitcomb, Louis L. and Gabor Fichtinger} } @article {Xu2013, title = {Accuracy analysis in MRI-guided robotic prostate biopsy}, volume = {8}, number = {1}, year = {2013}, pages = {211}, publisher = {Springer}, address = {Heidelberg, Germany, June 26-29}, author = {Xu, Helen and Andras Lasso and Peter Guion and Axel Krieger and Aradhana Kaushal and Anurag K. Singh and P.A. Pinto and Jonathan Coleman and R.L. Grubb III and Jean-Baptiste Lattouf and Cynthia Menard and Whitcomb, Louis L. and Gabor Fichtinger} } @article {Lasso2012b, title = {Planning and Targeting System for MRI-guided Robotic Interventions}, year = {2012}, month = {02/2012}, address = {Toronto, ON, Canada}, author = {Andras Lasso and Junichi Tokuda and Andriy Fedorov and Siddharth Vikal and Hadi Tadayyon and Aradhana Kaushal and Peter Guion and Gabor Fichtinger} } @article {Krieger2011b, title = {Development and Evaluation of an Actuated MRI-Compatible Robotic System for MRI-Guided Prostate Intervention}, journal = {IEEE/ASME Transactions on Mechatronics}, year = {2011}, month = {2011}, pages = {PP}, issn = {1941-014X}, doi = {10.1109/TMECH.2011.2163523}, author = {Axel Krieger and Sam Sang-Eun Song and Nathan Bongjoon Cho and Iulian Iordachita and Peter Guion and Gabor Fichtinger and Whitcomb, Louis L.} } @article {Krieger2011, title = {An MRI-Compatible Robotic System with Hybrid Tracking for MRI-Guided Prostate Intervention}, journal = {IEEE Transactions on Biomedical Engineering}, volume = {58 PP}, year = {2011}, month = {04/2011}, doi = {10.1109/TBME.2011.2134096}, author = {Axel Krieger and Iulian Iordachita and Peter Guion and Anurag K. Singh and Aradhana Kaushal and Cynthia Menard and P.A. Pinto and Kevin Camphausen and Gabor Fichtinger and Whitcomb, Louis L.} } @article {Lasso2011b, title = {Multi-slice-to-volume registration for reducing targeting error during MRI-guided transrectal biopsy}, volume = {4}, year = {2011}, month = {10/2011}, pages = {31}, address = {Arlington VA, October 12-13, 2011}, author = {Andras Lasso and Hadi Tadayyon and Aradhana Kaushal and Peter Guion and Gabor Fichtinger} } @article {Song2011b, title = {Needle Artifact Localization for Intraprocedural Biopsy Position Confirmation in 3T MRI-guided Robotic Transrectal Prostate Intervention}, volume = {4}, year = {2011}, month = {10/2011}, address = {Arlington VA, October 12-13, 2011}, author = {Sam Sang-Eun Song and Nathan Bongjoon Cho and Iulian Iordachita and Peter Guion and Gabor Fichtinger and Whitcomb, Louis L.} } @article {Song2011d, title = {A study of needle image artifact localization in confirmation imaging of MRI-guided robotic prostate biopsy}, year = {2011}, pages = {4834 - 4839}, publisher = {IEEE}, address = {Shanghai, China}, isbn = {978-1-61284-386-5}, doi = {10.1109/ICRA.2011.5980309}, author = {Sam Sang-Eun Song and Nathan Bongjoon Cho and Iulian Iordachita and Peter Guion and Gabor Fichtinger and Whitcomb, Louis L.} } @article {Tadayyon2011, title = {Target Motion Tracking in MRI-guided Transrectal Robotic Prostate Biopsy}, journal = {IEEE Transactions on Biomedical Engineering}, volume = {58}, year = {2011}, month = {08/2011}, pages = {3135-42}, issn = {0018-9294}, doi = {10.1109/TBME.2011.2163633}, author = {Hadi Tadayyon and Andras Lasso and Aradhana Kaushal and Peter Guion and Gabor Fichtinger} } @conference {Xu2010, title = {Accuracy validation for MRI-guided robotic prostate biopsy}, booktitle = {Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling}, year = {2010}, pages = {762517 - 762517-8}, publisher = {SPIE}, organization = {SPIE}, address = {San Diego, California, USA}, doi = {10.1117/12.844251}, author = {Xu, Helen and Andras Lasso and Siddharth Vikal and Peter Guion and Axel Krieger and Aradhana Kaushal and Whitcomb, Louis L. and Gabor Fichtinger} } @conference {Xu2010b, title = {Clinical Accuracy of Robot-Assisted Prostate Biopsy in Closed MRI Scanner}, booktitle = {The Hamlyn Symposium on Medical Robotics}, year = {2010}, address = {The Royal Society, London, UK, 25 May 2010}, url = {http://www.hamlyn-robotics.org/}, author = {Xu, Helen and Andras Lasso and Siddharth Vikal and Peter Guion and Axel Krieger and Aradhana Kaushal and Whitcomb, Louis L. and Gabor Fichtinger} } @conference {Xu2010c, title = {MRI-Guided Robotic Prostate Biopsy: A Clinical Accuracy Validation}, booktitle = {Medical Image Computing and Computer-Assisted Intervention (MICCAI 2010)}, year = {2010}, pages = {383-391}, publisher = {Springer}, organization = {Springer}, address = {Beijing, China}, isbn = {978-3-642-15710-3}, doi = {http://dx.doi.org/10.1007/978-3-642-15711-0_48}, author = {Xu, Helen and Andras Lasso and Siddharth Vikal and Peter Guion and Axel Krieger and Aradhana Kaushal and Whitcomb, Louis L. and Gabor Fichtinger} } @conference {Xu2010d, title = {MRI-Guided Transrectal Robotic Prostate Biopsy Validation}, booktitle = {The American Association of Physicists in Medicine (AAPM) Annual Meeting 2010, July 18-22}, volume = {37, 3128 (2010)}, year = {2010}, pages = {3128-3129}, address = {Philadelphia, Pennsylvania}, doi = {10.1118/1.3468153}, url = {http://dx.doi.org/10.1118/1.3468153}, author = {Xu, Helen and Andras Lasso and Siddharth Vikal and Peter Guion and Axel Krieger and Aradhana Kaushal and Whitcomb, Louis L. and Gabor Fichtinger} } @conference {Tadayyon2010b, title = {Target Motion Compensation in MRI-guided Prostate Biopsy with Static Images}, booktitle = {EMBC2010 - 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society}, year = {2010}, pages = {5416-5419}, publisher = {Crown}, organization = {Crown}, address = {Buenos Aires, Argentina}, author = {Hadi Tadayyon and Andras Lasso and Sean Gill and Aradhana Kaushal and Peter Guion and Gabor Fichtinger} } @conference {Krieger2008, title = {Design and Preliminary Clinical Studies of an MRI-Guided Transrectal Prostate Intervention System}, booktitle = {International Society of Magnetic Resonance in Medicine (ISMRM)}, year = {2008}, author = {Axel Krieger and Peter Guion and Csaba Csoma and Iulian Iordachita and Anurag K. Singh and Aradhana Kaushal and Cynthia Menard and Gabor Fichtinger and Whitcomb, Louis L.} } @conference {Krieger2008b, title = {MRI Guided Prostate Biopsy and Marker Placements}, booktitle = {Workshop on Clinical Image-Guided Therapy: Opportunities and Needs}, year = {2008}, author = {Axel Krieger and Peter Guion and Csaba Csoma and Iulian Iordachita and Anurag K. Singh and Aradhana Kaushal and Whitcomb, Louis L. and Gabor Fichtinger} } @article {Krieger2007a, title = {Design and preliminary accuracy studies of an MRI-guided transrectal prostate intervention system}, journal = {Medical image computing and computer-assisted intervention (MICCAI)}, volume = {10}, number = {Pt 2}, year = {2007}, pages = {59{\textendash}67}, publisher = {Department of Mechanical Engineering, Johns Hopkins University, Baltimore, USA}, abstract = {

This paper reports a novel system for magnetic resonance imaging (MRI) guided transrectal prostate interventions, such as needle biopsy, fiducial marker placement, and therapy delivery The system utilizes a hybrid tracking method, comprised of passive fiducial tracking for initial registration, subsequent incremental motion measurement along the degrees of freedom using fiber-optical encoders, mechanical scales Targeting accuracy of the system is evaluated in prostate phantom experiments Achieved targeting accuracy, procedure times were found to compare favorably with existing systems using passive, active tracking methods Moreover, the portable design of the system using only standard MRI image sequences, minimal custom scanner interfacing allows the system to be easily used on different MRI scanners

}, keywords = {Algorithms, Artificial Intelligence, Automated, Biopsy, Computer-Assisted, Equipment Design, Equipment Failure Analysis, Humans, Image Enhancement, Image Interpretation, Imaging, instrumentation/methods, Interventional, Magnetic Resonance Imaging, Male, methods, Needle, pathology/surgery, Pattern Recognition, Pilot Projects, Prostatectomy, Prostatic Neoplasms, Rectum, Reproducibility of Results, Robotics, Sensitivity, Specificity, Three-Dimensional, User-Computer Interface}, author = {Axel Krieger and Csaba Csoma and Iulian Iordachita and Peter Guion and Anurag K. Singh and Gabor Fichtinger and Whitcomb, Louis L.} } @article {Singh2007a, title = {Patient selection determines the prostate cancer yield of dynamic contrast-enhanced magnetic resonance imaging-guided transrectal biopsies in a closed 3-Tesla scanner}, journal = {British Journal of Urology international}, volume = {101}, number = {2}, year = {2007}, month = {Jan}, pages = {181{\textendash}185}, publisher = {Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1642, USA Anurag Singh@RoswellPark org}, abstract = {

OBJECTIVE: To evaluate the cancer yield of transrectal prostate biopsies in a 3-T magnetic resonance imaging (MRI) scanner in patients with elevated prostate specific antigen (PSA) levels, recent negative transrectal ultrasonography (TRUS)-guided prostate biopsies PATIENTS AND METHODS: Between July 2004, November 2005, patients with at least one previous negative prostate biopsy within the previous 12 months had MRI-guided biopsy of the prostate in a 3-T MRI scanner Patients with previous positive biopsies for cancer were excluded Target selection was based on T2-weighted imaging, dynamic contrast-enhanced (DCE) imaging studies RESULTS: Thirteen patients were eligible; their median (range) age was 61 (47-74) years, PSA value 4 90 (1 3-12 3) ng/mL Most patients had one previous negative biopsy (range 1-4) Four patients had a family history of prostate cancer There were 37 distinct targets based on T2-weighted imaging Fifteen of 16 distinct DCE abnormalities were co-localized with a target based on T2-weighted imaging Despite this correlation, only one of 13 patients had a directed biopsy positive for cancer Including systematic biopsies, two of 13 patients had a biopsy positive for prostate cancer One patient had prostate intraepithelial neoplasia, one had atypical glands in the specimen CONCLUSION: The prostate-cancer yield of transrectal biopsies in a 3-T MRI scanner, among patients with recent negative TRUS-guided prostate biopsies, is similar to repeat systematic TRUS-guided biopsy DCE correlates with T2-imaging but does not appear to improve prostate cancer yield in this population

}, keywords = {Aged, Biopsy, blood, Cohort Studies, Contrast Media, diagnosis, Digital Rectal Examination, Humans, Interventional, Magnetic Resonance Imaging, Male, methods, Middle Aged, Needle, pathology, Patient Selection, Predictive Value of Tests, Prostate, Prostate-Specific Antigen, Prostatic Neoplasms, Sensitivity, Specificity, standards, Ultrasonography}, doi = {10 1111/j 1464-410X 2007 07219 x}, url = {http://dx doi org/10 1111/j 1464-410X 2007 07219 x}, author = {Anurag K. Singh and Axel Krieger and Jean-Baptiste Lattouf and Peter Guion and R.L. Grubb III and Paul Albert and Greg Metzger and Karen Ullman and Sharon Smith and Gabor Fichtinger and Iclal Ocak and Peter Choyke and Cynthia Menard and Jonathan Coleman} } @conference {Krieger2007, title = {Phantom Experiments with a Novel MR-Guided Transrectal Prostate Interventional System}, booktitle = {International Society of Magnetic Resonance in Medicine (ISMRM)}, year = {2007}, author = {Axel Krieger and Csaba Csoma and Peter Guion and Iulian Iordachita and Greg Metzger and Di Qian and Anurag K. Singh and Whitcomb, Louis L. and Gabor Fichtinger} } @article {Singh2007b, title = {Simultaneous integrated boost of biopsy proven and MRI defined dominant intra-prostatic lesions to 95 Gray with IMRT: early results of a phase I NCI study}, journal = {Radiation Oncology}, volume = {2}, year = {2007}, pages = {36}, publisher = {Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, USA singhanu@yahoo com}, abstract = {

BACKGROUND: To assess the feasibility, early toxicity of selective, IMRT-based dose escalation (simultaneous integrated boost) to biopsy proven dominant intra-prostatic lesions visible on MRI METHODS: Patients with localized prostate cancer, an abnormality within the prostate on endorectal coil MRI were eligible All patients underwent a MRI-guided transrectal biopsy at the location of the MRI abnormality Gold fiducial markers were also placed Several days later patients underwent another MRI scan for fusion with the treatment planning CT scan This fused MRI scan was used to delineate the region of the biopsy proven intra-prostatic lesion A 3 mm expansion was performed on the intra-prostatic lesions, defined as a separate volume within the prostate The lesion + 3 mm, the remainder of the prostate + 7 mm received 94 5/75 6 Gray (Gy) respectively in 42 fractions Daily seed position was verified to be within 3 mm RESULTS: Three patients were treated Follow-up was 18, 6, and 3 months respectively Two patients had a single intra-prostatic lesion One patient had 2 intra-prostatic lesions All four intra-prostatic lesions, with margin, were successfully targeted, treated to 94 5 Gy Two patients experienced acute RTOG grade 2 genitourinary (GU) toxicity One had grade 1 gastrointestinal (GI) toxicity All symptoms completely resolved by 3 months One patient had no acute toxicity CONCLUSION: These early results demonstrate the feasibility of using IMRT for simultaneous integrated boost to biopsy proven dominant intra-prostatic lesions visible on MRI The treatment was well tolerated

}, keywords = {adverse effects/methods, Biopsy, epidemiology, epidemiology/radiotherapy, Follow-Up Studies, Humans, Intensity-Modulated, Magnetic Resonance Imaging, Male, National Cancer Institute (U S ), Patient Selection, Prostatic Neoplasms, Questionnaires, Radiotherapy, Radiotherapy Dosage, United States}, doi = {10 1186/1748-717X-2-36}, url = {http://dx doi org/10 1186/1748-717X-2-36}, author = {Anurag K. Singh and Peter Guion and Nancy Sears-Crouse and Karen Ullman and Sharon Smith and Paul Albert and Gabor Fichtinger and Peter Choyke and Sheng Xu and Jochen Kruecker and Bradford Wood and Axel Krieger and Holly Ning} } @conference {Krieger2006a, title = {Accuracy of Hybrid Tracking for a Novel MR-Guided Transrectal Prostate Interventional Device}, booktitle = {6th Interventional MRI Symposium}, year = {2006}, pages = {143-145}, author = {Axel Krieger and Iulian Iordachita and Greg Metzger and Peter Guion and Ergin Atalar and Gabor Fichtinger and Whitcomb, Louis L.} } @article {Menard2005, title = {An Interventional MRI Technique for the Molecular Characterization of Intra-Prostatic Dynamic Contrast Enhancement}, journal = {Molecular Imaging}, volume = {4 No 1}, year = {2005}, pages = {63-66}, author = {Cynthia Menard and Robert Susil and Peter Choyke and Jonathan Coleman and R.L. Grubb III and Ahmed Gharib and Axel Krieger and Peter Guion and David Thomasson and Karen Ullman and Sandeep Gupta and Virginia Espina and Lance Liotta and Emanuel Petricoin and Gabor Fichtinger and Whitcomb, Louis L. and Ergin Atalar and Norman Coleman and Kevin Camphausen} } @conference {Krieger2005, title = {MRI Guided Prostate Interventions in 3T}, booktitle = {International Society of Magnetic Resonance in Medicine (ISMRM)}, year = {2005}, author = {Axel Krieger and Peter Guion and Abdel-Monem El-Sharkawy and Greg Metzger and Jonathan Coleman and R.L. Grubb III and Di Qian and Ahmed Gharib and David Thomasson and Anurag K. Singh and Gabor Fichtinger and Whitcomb, Louis L. and Cynthia Menard and Ergin Atalar} } @conference {Menard2004, title = {Integrating Diagnostic and Interventional MRI for the Molecular Characterization of Prostate Cancer}, booktitle = {5th Interventional MRI Symposium}, year = {2004}, author = {Cynthia Menard and Robert Susil and Peter Choyke and Jonathan Coleman and R.L. Grubb III and Axel Krieger and Ahmed Gharib and Peter Guion and David Thomasson and Jacek Capala and Sandeep Gupta and Gabor Fichtinger and Whitcomb, Louis L. and Norman Coleman and Kevin Camphausen and Ergin Atalar} } @conference {Menard2004a, title = {MRI For The Molecular Characterization Of Prostate Cancer Integrating Diagnostic And Interventional MRI For The Molecular Characterization Of Prostate Cancer}, booktitle = {5th Interventional MRI Symposium}, year = {2004}, pages = {26}, author = {Cynthia Menard and Robert Susil and Peter Choyke and Jonathan Coleman and R.L. Grubb III and Axel Krieger and Ahmed Gharib and Peter Guion and David Thomasson and Jacek Capala and Sandeep Gupta and Gabor Fichtinger and Whitcomb, Louis L. and Norman Coleman and Kevin Camphausen and Ergin Atalar} }