@article {Choi2020, title = {3D Modeling of Surgically Implanted Stent-Based Valves in the Mitral Position in Children}, journal = {The Annals of Thoracic Surgery}, year = {2020}, doi = {10.1016/j.athoracsur.2020.02.020}, url = {https://doi.org/10.1016/j.athoracsur.2020.02.020}, author = {Perry S. Choi and HannahH Nam and Andras Lasso and Christian Herz and Simon Drouin and David M. Harrild and Michael Quartermain and Gabor Fichtinger and Christopher E. Mascio and Sitaram Emani and MatthewA Jolley} } @article {NGUYEN2019, title = {Dynamic Three-Dimensional Geometry of the Tricuspid Valve Annulus in Hypoplastic Left Heart Syndrome with a Fontan Circulation}, journal = {Journal of the American Society of Echocardiography}, year = {2019}, abstract = {

Background Tricuspid regurgitation (TR) is a significant contributor to morbidity and mortality in patients with hypoplastic left heart syndrome. The goal of this study was to characterize the dynamic annular motion of the tricuspid valve in patients with HLHS with a Fontan circulation and assess the relation to tricuspid valve function. Methods Tricuspid annuli of 48 patients with HLHS with a Fontan circulation were modeled at end-diastole, mid-systole, end-systole, and mid-diastole using transthoracic three-dimensional echocardiography and custom code in 3D Slicer. The angle of the anterior papillary muscle (APM) relative to the annular plane in each systolic phase was also measured. Results Imaging was performed 5.0\ years (interquartile range, 2{\textendash}11\ years) after Fontan operation. The tricuspid annulus varies in shape significantly throughout the cardiac cycle, changing in sphericity (P\ \<\ .001) but not in annular height or bending angle. In univariate modeling, patients with significant TR had larger changes in septolateral diameter, lateral quadrant area, and posterior quadrant area (P\ \<\ .05 for all) as well as lower (more laterally directed) APM angles (P\ \<\ .001) than patients with mild or less TR. In multivariate modeling, a 1\ mm/(body surface area)0.5 increase in the maximum change in septolateral diameter was associated with a 1.7-fold increase in having moderate or greater TR, while a 10{\textdegree} decrease in APM angle at mid-systole was associated with an almost 2.5-fold increase in moderate or greater TR (P\ <=\ .01 for all). Conclusions The tricuspid annulus in patients with HLHS with a Fontan circulation changes in shape significantly throughout the cardiac cycle but remains relatively planar. Increased change in septolateral diameter and decreased APM angle are strongly associated with the presence of TR. These findings may inform annuloplasty methods and subvalvular interventions in these complex patients.

}, keywords = {Congenital heart disease, Echocardiography, Valvular heart disease}, issn = {0894-7317}, doi = {https://doi.org/10.1016/j.echo.2019.01.002}, url = {http://www.sciencedirect.com/science/article/pii/S0894731719300021}, author = {Alexander V. Nguyen and Andras Lasso and HannahH Nam and Jennifer Faerber and Ahmed H. Aly and Alison M. Pouch and Adam B. Scanlan and FrancisX McGowan and Laura Mercer-Rosa and Meryl S. Cohen and John Simpson and Gabor Fichtinger and MatthewA Jolley} } @article {Lasso2018, title = {Interaction with Volume-Rendered Three-Dimensional Echocardiographic Images in Virtual Reality}, journal = {J Am Soc Echocardiogr}, volume = {31}, number = {10}, year = {2018}, month = {10}, pages = {1158-60{\textendash}}, abstract = {

Three-dimensional (3D) imaging is increasingly important in echocardiography. However, viewing of 3D images on a flat, two-dimensional screen is a barrier to comprehension of latent information. There have been previous attempts to visualize the full 3D nature of the data, but they have not been widely adopted. For example, 3D printing offers realistic interaction but is time consuming, has limited means for the observer to move into or through the model, and is not yet practical for routine clinical use. Furthermore, the heart beats, and 3D printed models are static. Stereoscopic viewing on 2D screens (as at a movie theater) is possible but is expensive, may not provide an immersive experience, and does not have integrated 3D input devices (controllers).

}, author = {Andras Lasso and HannahH Nam and PatrickV Dinh and Csaba Pinter and Jean-ChristopheC. Fillion-Robin and Steve Pieper and Sankhesh Jhaveri and Jean-Baptiste Vimort and Ken Martin and Mark Asselin and FrancisX McGowan and Ron Kikinis and Gabor Fichtinger and MatthewA Jolley} } @article {doi:10.1002/ccd.27962, title = {Toward predictive modeling of catheter-based pulmonary valve replacement into native right ventricular outflow tracts}, journal = {Catheterization and Cardiovascular Interventions}, year = {2018}, month = {11/2018}, abstract = {

Abstract Background Pulmonary insufficiency is a consequence of transannular patch repair in Tetralogy of Fallot (ToF) leading to late morbidity and mortality. Transcatheter native outflow tract pulmonary valve replacement has become a reality. However, predicting a secure, atraumatic implantation of a catheter-based device remains a significant challenge due to the complex and dynamic nature of the right ventricular outflow tract (RVOT). We sought to quantify the differences in compression and volume for actual implants, and those predicted by pre-implant modeling. Methods We used custom software to interactively place virtual transcatheter pulmonary valves (TPVs) into RVOT models created from pre-implant and post Harmony valve implant CT scans of 5 ovine surgical models of TOF to quantify and visualize device volume and compression. Results Virtual device placement visually mimicked actual device placement and allowed for quantification of device volume and radius. On average, simulated proximal and distal device volumes and compression did not vary statistically throughout the cardiac cycle (P = 0.11) but assessment was limited by small sample size. In comparison to actual implants, there was no significant pairwise difference in the proximal third of the device (P \> 0.80), but the simulated distal device volume was significantly underestimated relative to actual device implant volume (P = 0.06). Conclusions This study demonstrates that pre-implant modeling which assumes a rigid vessel wall may not accurately predict the degree of distal RVOT expansion following actual device placement. We suggest the potential for virtual modeling of TPVR to be a useful adjunct to procedural planning, but further development is needed.

}, keywords = {Magnetic Resonance Imaging, percutaneous pulmonary valve implantation, prosthetic heart valve, tetralogy of Fallot}, doi = {10.1002/ccd.27962}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/ccd.27962}, author = {MatthewA Jolley and Andras Lasso and HannahH Nam and Dinh, Patrick V. and Adam B. Scanlan and Alexander V. Nguyen and Anna Ilina and Morray, Brian and Glatz, Andrew C. and FrancisX McGowan and Whitehead, Kevin and Dori, Yoav and Robert C. Gorman and Robert C. Gorman and Gabor Fichtinger and Gillespie, Matthew J.} }