@article {NasuteFauerbach2021,
	title = {Lack of definitive presurgical pathological diagnosis is associated with inadequate surgical margins in breast-conserving surgery},
	journal = {European Journal of Surgical Oncology},
	year = {2021},
	month = {06/2021},
	abstract = {<p>Purpose To determine the impact of definitive presurgical diagnosis on surgical margins in breast-conserving surgery (BCS) for primary carcinomas; clinicopathological features were also analyzed. Methods This retrospective study included women who underwent BCS for primary carcinomas in 2016 and 2017. Definitive presurgical diagnosis was defined as having a presurgical core needle biopsy (CNB) and not being upstaged between biopsy and surgery. Biopsy data and imaging findings including breast density were retrieved. Inadequate surgical margins (IM) were defined per latest ASCO and ASTRO guidelines. Univariable and multivariable analyses were performed. Results 360 women (median age, 66) met inclusion criteria with 1 having 2 cancers. 82.5\% (298/361) were invasive cancers while 17.5\% (63/361) were ductal carcinoma in situ (DCIS). Most biopsies were US-guided (284/346, 82.0\%), followed by mammographic (60/346, 17.3\%), and MRI-guided (2/346, 0.6\%). US and mammographic CNB yielded median samples of 2 and 4, respectively, with a 14G needle. 15 patients (4.2\%) lacked presurgical CNB. The IM rate was 30.0\%. In multivariable analysis, large invasive cancers (\&gt;20\&nbsp;mm), dense breasts, and DCIS were associated with IM (p\&nbsp;=\&nbsp;0.029, p\&nbsp;=\&nbsp;0.010, and p\&nbsp;=\&nbsp;0.013, respectively). Most importantly, lack of definitive presurgical diagnosis was a risk factor for IM (OR, 2.35; 95\% CI: 1.23{\textendash}4.51, p\&nbsp;=\&nbsp;0.010). In contrast, neither patient age (\&lt;50) nor aggressive features (e.g., LVI) were associated with IM. Conclusion Lack of a definitive presurgical diagnosis was associated with a two-fold increase of IM in BCS; other risk factors were dense breasts, large invasive cancers, and DCIS.</p>
},
	keywords = {Breast cancer, Breast-conserving surgery (BCS), Core needle biopsy and vacuum-assisted biopsy, Definitive presurgical diagnosis, High-risk lesions, Surgical margins},
	issn = {0748-7983},
	doi = {https://doi.org/10.1016/j.ejso.2021.05.047},
	url = {https://www.sciencedirect.com/science/article/pii/S0748798321005424},
	author = {Paola V. Nasute Fauerbach and Kathrin Tyryshkin and Silvia Perez Rodrigo and John Rudan and Gabor Fichtinger and Michael Reedijk and Sonal Varma and David M. Berman}
}
