A rapid approach to monitor ablative therapy through optimizing shape, elasticity parameters is introduced Our motivating clinical application is targeting, intraoperative monitoring of hepatic tumor thermal ablation, but the method translates to the generic problem of encapsulated stiff masses (solid organs, tumors, ablated lesions, etc ) in ultrasound imaging The approach involves the integration of the following components: a biomechanical computational model of the tissue, a correlation approach to estimate/track tissue deformation, and an optimization method to solve the inverse problem, recover the shape parameters in the volume of interest Successful convergence, reliability studies were conducted on simulated data Then ex-vivo studies were performed on 18 ex-vivo bovine liver samples previously ablated under ultrasound monitoring in controlled laboratory environment While B-mode ultrasound does not clearly identify the development of necrotic lesions, the proposed technique can potentially segment the ablation zone The same framework can also yield both partial, full elasticity reconstruction